The Immortal Life of Henrietta Lacks (HBO, Saturday 8:00 p.m.) – The Oprah-starring vehicle focuses on the true story of Henrietta Lacks, a woman whose DNA is the reason why we have a cure for polio and a ton of other diseases. Oprah plays Henrietta’s daughter Deborah, who is trying to figure out her mother’s story and how her cells were taken against her will to help further biomedical research.
Silicon Valley (HBO, Sunday 10:00 p.m.) — In the Season 4 premiere, the guys struggle to find funding for Pied Piper’s video-chat app to keep up with their rapidly growing user base.
Feud: Bette and Joan (FX, Sunday 10:00 p.m.) – In the season finale, Joan agrees to a new role in a feature film despite her failing health and later, Bette takes a hard look at her misplaced feud with Joan when she’s faced with a new rival.
First Dates (NBC, Friday 8:00 p.m.) — One dater has a hefty checklist that her match hopes to meet and another dater is caught in a web of lies.
Rosewood (Fox, Friday 8:00 p.m.) – Rosewood and Villa grow close after a school teacher’s untimely death pulls them into the world of human trafficking.
The Toy Box (ABC, Friday 8:00 p.m.) – Tonight’s inventions include sinkable building blocks for pools, a life-size construction toy and a therapy doll designed to help kids express their emotions.
Shark Tank (ABC, Friday 9:00 p.m.) — Newlyweds and bodybuilders from Dallas create a fitness apparel line that caters to the woman who loves building her booty, a Ph.D. scientist and surfer from Honolulu, Hawaii, invent a rescue signal for people that could make the difference between life and death, and two entrepreneurs from New Albany, Ohio, hope for a deal with their unique slash-proof and water-resistant backpacks.
Doctor Who (BBC, Saturday 9:00 p.m.) – The Doctor and Bill head to a fantastical city on a far off planet but arrive to find it completely uninhabited.
The Son (AMC, Saturday 9:00 p.m.) – In the past, a young Eli faces a life or death decision while in 1915, the McCulloughs enact a dangerous plan to take the fight to their enemy.
Training Day (CBS, Saturday 9:00 p.m.) – When a community organizer is accidentally killed in a gang shooting, Frank and Kyle seek justice.
Bob’s Burgers (Fox, Sunday 8:00 p.m.) – Linda and the girls have a dinner date at a strange restaurant while Gene and Bob attend the last-ever rock-and-roll laser show at the planetarium.
Little Big Shots (NBC, Sunday 8:00 p.m.) – The tiny performers include a 6-year-old snail whisperer, a family of fiddlers and step dancers, a singer from Wales, quick-change artists, and a 5-year-old pianist.
NCIS: Los Angeles (CBS, Sunday 8:00 p.m.) – A former Navy commander kidnaps a corrupt Veterans Affairs administrator who has been siphoning funds, spurring the team to partner with one of Hetty’s former Vietnam war colleagues to track them down.
Once Upon a Time (ABC, Sunday 8:00 p.m.) – Zelena goes against Regina and tries to stop the Black Fairy on her own while Emma and Hook’s upcoming wedding causes chaos in the Charming household when the family disagrees over nuptial planning.
The White Princess (Starz, Sunday 8:00 p.m.) – Henry tries to establish his rule by setting off on a royal tour as Lizzie struggles with her loyalties to her family and the child she’s expecting with her new husband.
Making History (Fox, Sunday 8:30 p.m.) — Dan, Deb and Chris are stuck in 1920s Chicago, where Al Capone holds their time-travel bag hostage. While Chris decides to use history to take down Capone, Deb and San try to befriend him and teach him how to be a better mobster.
Chicago Justice (NBC, Sunday 9:00 p.m.) – Stone’s obsession with getting justice for a young girl killed in a gang shooting instigated on social media ends up endangering the family of a witness.
Madam Secretary (CBS, Sunday 9:00 p.m.) — When warring rebel groups threaten Elizabeth’s Somalian food relief efforts and kidnap an American aide there, she reluctantly considers asking a notorious Russian arms dealer for help.
Match Game (ABC, Sunday 9:00 p.m.) — Celebrity panelists include Jason Alexander, Cheryl Hines, Joe Lo Truglio, Ellie Kemper, Wayne Brady, and Caroline Rhea.
The Leftovers (HBO, Sunday 9:00 p.m.) – Nora heads to St. Louis under order from the Department of Sudden Departure to investigate a possible scam.
The Last Man on Earth (Fox, Sunday 9:30 p.m.) – Todd and Tandy begin feuding which threatens the group’s plans to throw a party celebrating every major holiday.
American Crime (ABC, Sunday 10:00 p.m.) — Dustin’s life is in danger following a fatal altercation at the Webcam house, so he reaches out for help from Kimara, who is struggling with a difficult moral dilemma and decides to take time off from work at the shelter.
Billions (Showtime, Sunday 10:00 p.m.) – Chuck is in line for a promotion and Axe has his hands full dealing with family drama.
Elementary (CBS, Sunday 10:00 p.m.) – Holmes and Watson investigate the mysterious death of a magician killed while performing a stunt.
Into the Badlands (AMC, Sunday 10:00 p.m.) – The Widow makes a dangerous alliance and Sunny and Bajie meet with an unexpected friend and face an old enemy.
Shades of Blue (NBC, Sunday 10:00 p.m.) – Harlee tries to unite the team for an illegal mission to repay Tufo’s brother’s debt to a local drug dealer as Stahl makes good on his threat to the crew.
Veep (HBO, Sunday 10:30 p.m.) – Amy release an attack ad, Jonah discovers how to get ahead in politics, and Selena considers opening her own presidential library.
LATE NIGHT GUESTS
The Tonight Show Starring Jimmy Kimmel: Salma Hayek, W. Kamau Bell, Barry Manilow
The Late Show With Stephen Colbert: Rosario Dawson, Renee Elise Goldsberry, Moshe Kasher