Here are ten of those instances.
1. Saved by the Bell.
Role: Lisa. Original Character Description: White, Jewish princess from Long Island.
Cast Instead: Lark Voorhies
Role: Mr. Belding.
Original Character Description: Male, Black, in his 50s.
Cast Instead: Dennis Haskins
Role: Agent Dana Scully
Original Character Description: Someone “taller, leggier, blonder and breastier” than the woman that Chris Carter wanted for the role, Gillian Anderson.
Cast Instead: Gillian Anderson
3. Agents of Shield
Role: Agent Althea Rice
Original Character Description: A white woman, known as “The Cavalry.”
Cast Instead: Ming-Na Wen (and changed the character name to Melinda May)
Role: Sun-Hwa Kwon
Original Description: Did not exist
Cast Instead: Yunjin Kim, who actually auditioned for Kate, but was liked so much, they created the character of Sun-Hwa Kwon for her.
5. House, M.D.
Role: Gregory House
Original Description: No non-Americans, and especially no British actors (because their American accents were poor).
Cast Instead: Hugh Laurie (who director/exec producer Bryan Singer didn’t realize was not American because of his flawless Boston accent. In fact, Singer singled Laurie out as an example of the kind of compelling American actor he had been looking for.)